This work is concerned with application of simple, precise, accurate and reproducible reverse phase high performance liquid chromatographic (RP-HPLC) method for simultaneous estimation of Hydralazine Hydrochloride (HLZ) and Propranolol (PRO) on RP Phenomenex C18 column (250 mm x 4.6 mm i.d., 5 μm particle size) using Acetonitrile +0.25 ml Triethylamine - Water (35:65%) pH adjusted to 3.5 with O- phosphoric acid as mobile phase at a flow rate of 1.0 ml/min and the detection wavelength was 273 nm. The retention time for HLZ and PRO was found to be 5.297 and 3.183 min, respectively. Proposed method was validated for precision, accuracy, linearity range, robustness.
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